Diabetes under discussion. Prevention to the table. This ‘Diabetes’ month we share with you an article on Diabetes and how Probiotics could offer a cure. We often say it is ALL in the gut. Well I believe it is! Prevention, maintenance and the cure! We share the following article is written for Diabetes Research Connection and it demonstrates the findings that Type 1 Diabetes originates in the gut.
“Two separated pieces of research have found that the development of type 1 diabetes is likely caused by the gut, and therefore, a type of probiotic could be the cure.
Scientists from several European and US institutions studied 33 Finnish infants over three years from birth who were genetically predisposed to type 1 diabetes. They discovered that four children in the group that developed type 1 diabetes had 25% less types of bacteria in their guts than other children. The same four infants were also found to have more amounts of a specific bacteria that is known to trigger gut inflammation.
This could be a prelude to type 1 diabetes as the bacteria causes the immune system to mistakenly attack and destroy beta cells in the pancreas that usually make insulin and monitor glucose levels.
“We know from previous human studies that changes in gut bacterial composition correlate with the early development of type 1 diabetes, and that the interactions between bacterial networks may be a contributing factor in why some people at risk for the disease develop type 1 diabetes and others don’t,” said Jessica Dunne, Director of Discovery Research at Juvenile Diabetes Research Foundation (JDRF), a UK charity which funded the study.
“This is the first study to show how specific changes in the microbiome are affecting the progression to symptomatic T1D.”
By being able to understand how the community of microorganisms in our guts, (known as a microbiome) and which species are absent in the gastrointestinal tracts of children, the researchers believe they can slow down the progression of type 1 diabetes. Probiotics could be the cure for type 1 diabete!!!
Cornell University researchers have a similar idea, but they have been working on a treatment that involves regulating insulin by engineering the bacteria found in our guts.
The scientists took a strain of bacteria known as Lactobacillus gasseri – a type of bacteria found in probiotic yoghurts – and engineered the bacteria to be able to secrete a hormone called glucagon-like peptide-1 (GLP-1).
When they fed this engineered probiotic to a group of diabetic rats for 90 days, they discovered that the bacteria triggered the upper intestinal epithelial cells in the rats to convert into cells that acted a lot like the pancreatic beta cells.
It’s moving the centre of glucose control from the pancreas to the upper intestine,” said John March, professor of biological and environmental engineering at Cornell University and the paper’s senior author.
Source: The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes”
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